Increase CBD Bioavailability: Health Consciousness

Bioavailability is the physiologic availability of a particular dose as distinct from its chemical potency. For example, if 3 mg of a drug are ingested, the whole 3 mg will not be available for use by the body. Some of it will be extricated through physiological processes. However, this level is affected by a few things like method of administration. 

Method of Administration

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Intravenous administration offers 100% bioavailability. This is because the whole amount is delivered right into the blood stream. In the case of rectal administration, only half of the drug will go through the first pass metabolisms. This is because only some of the vessels in the rectum lead to the liver. Transdermal offers 80% bioavailability with a slow absorption and prolonged duration of action. Please note difference between transdermal and topical. Topical is only skin-deep. Transdermal reaches the blood vessels under the dermal layers.  With CBD, most favor sublingual and inhalation as these administration methods bypass the metabolism. The effects are almost immediate. Sublingually, the CBD is absorbed into the blood stream through the vessels under the mouth. By inhalation, the CBD goes to the lungs. The lungs are rich in vessels and veins. 

Orally administered CBD is broken down then delivered to the liver where the first pass effect takes place. This is a pre-systemic metabolism enroute to the site of action. The effect is measured by extraction ratio. This ration can be affected by chemical instability, which would influence absorption of the CBD. The size of the particle to be absorbed also matters a lot. This is why it is preferred to take the cannabinoid in the CBD form as opposed to the CBDa form. CBDa is an acidic form of CBD. This form is considered inactive. The structure of the CBD product also matters. Diluents are used in the case of oils and other liquids. Excipients are used in the case of pills. The compression pressure of these pills should not make the product too tightly bound that it becomes difficult to absorb. 

The administration method should be a personal choice. However, preference and comfort should not come before bioavailability. You should think about how much of the CBD would be made available first before thinking about how fun it will be to snack on CBD cookies. There are ways to enhance the bioavailability. This is done by influence the endocannabinoid activity. The endocannabinoid system is responsible for CBD mechanism. Through enhancement of this system, bioavailability will be positively impacted. 

  1. Exercise

Physical activity up regulates receptors and enhances receptor sensitivity so that it is more receptive. In fact, there is a hypothesis that the endocannabinoid system is partly or wholly attributable for the runner’s high. This is a state of euphoria experienced after a run. It is a complete turnaround in mood for a more excitable state. 

A study was conducted with trained male college students. They were put on treadmills and stationary bikes. The activity ran for 50 minutes at a heart rate of 70-80 % of the maximum. Afterwards, results f tests showed an increased level of anandamide in the blood plasma. However, further research is required t ascertain the nature and mechanism of endocannabinoid response. 

  1. Cold Showers

How strange is this, right? Well, it has been found that cold exposure can significantly up regulate the endocannabinoid system. It increases the endocannabinoid levels and density of CB1 neurons. 

A study was conducted to look into this idea. It was found that cold exposure lead to increased activity of Brown Adipose Tissue. The BAT is responsible for energy expenditure. Low BAT activity will directly bring about aging and obesity. An increase in endocannabinoid tone was realized through up regulation of BAT activity. 

  1. Osteopathy

This is a holistic practice based on manipulation and massage of skeleton and musculature. Studies have found that after a treatment, the patient experiences more 150% increase in endocannabinoid levels. The practice takes advantage of the dynamic interaction between body, mind, and soul. It usually constitutes a lifestyle change and massages. In some cases, it might involve some supplements. 

  1. Stress Management

Stress causes production a hormone called cortisol. High levels of cortisol cause a reduction in cannabinoid receptors. It also causes a lower cannabinoid binding ability in addition to a lower endocannabinoid level. 

  1. Dark Chocolate 

What a delicious suggestion! Dark chocolate has been found to contain the endocannabinoid anandamide. In addition to this, it also contains some compounds that work to slow down break down of anandamide. Chocolate is also a stress reliever in the sense that it reduces the level of cortisol in the body. 

  1. Alcohol 

Most lifestyle professionals will advice a downward adjustment in the amount of alcohol consumed by a human being. A little bit of wine is good for digestion but in excess, alcohol dampens the endocannabinoid system and reduces endocannabinoid signaling. This is why one is asked to give the alcohol a break when under treatment. The drugs will require the endocannabinoid system to work at full capacity. 

  1. Diet
  • Omega 3 Fatty Acids

The body cannot make endocannabinoids without omega 3. The body is unable to make omega 3 on its own so it relies entirely upon the diet to derive it. A study was conducted in 2011 where mice were found to develop broken down cannabinoid receptors due to deficiency of Omega 3. 

Omega 3 can be found in fish. It also present in some plants. However, phenolic omega 3 is difficult to break down. Soy beans and flax seeds are excellent sources of plant omega 3. There are also dietary supplements in the market that help with this issue in the event one cannot access these. One should aim to achieve a balance between omega 6 and omega 3. They are both important fatty acids. 

  • Vegetable Oil

CBD is not water-soluble. It is best dissolved in oil. Vegetable oil offers the best backdrop for CBD products. A study was conducted where it was found that CBD has a high affinity to chylomicrons. These are particles in the small intestine. They transport lipids to the blood stream through the lymphatic system. This means that through these organisms, the CBD can bypass the liver and consequently, the first pass effect. However, the CBD would have to be dissolved in dietary lipids to allow for effective transport through the lymphatic system. The more oil there is, the more lymph flow there is. This would effectively increase the bioavailability of a CBD product. 

  • Flavonoids

These are phytonutrients. The level of the polyphenolic compounds is directly proportional to the amount of pigment. This means that the more colorful the fruit or vegetable, the more flavonoids it contains. These compounds inhibit FAAH. FAAH is an element that breaks down endocannabinoids like anandamide. A higher level of anandamide means a stronger endocannabinoid system and receptor network. This means a higher ability for CBD to bind and work through the receptors. 

Tweak Bioavailability not the Dosage

An increase in bioavailability means that you can take a lower dose and still benefit immensely. This in turn means a lower cost. An increase bioavailability also means that the endocannabinoid system is working at higher capacity. A better working endocannabinoid system is a great precursor to good health. One is less prone to opportunistic diseases. None of the above measures are anything you have to go out of your way for, they are regular things that doctors advise for better health. Increasing CBD bioavailability just happens to be one more reason to be more health conscious.

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